Speakers
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Dr Graham Slack
Dr. Slack earned his doctor of medicine at the University of British Columbia. He completed a residency in General Pathology at the University of Alberta and a fellowship in hematopathology at the Massachusetts General Hospital/Harvard Medical School. He is a practicing pathologist at BC Cancer – Vancouver Centre and a clinical associate professor at the University of British Columbia.
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Dr Tracy TuckerDr. Tracy Tucker is a Cytogeneticist and Molecular Geneticist
at BC Cancer Genetic and Genomics Laboratory and a Clinical Associate Professor in the Department of Pathology and Laboratory Medicine at the UBC. She completed her PhD and post-doctoral fellowship in Medical Genetics at the University of British Columbia. She runs the molecular genetics training for UBC pathology residents and has an interest in education and curriculum mapping as well as trouble-shooting molecular assays for clinical application.
Objectives
• Understand B-cell and T-cell clonality testing and its utility and limitations in identifying lymphoid malignancies
• Understand the genetic and genomic changes seen in diffuse large B-cell lymphoma, including: Cell of origin gene expression profiling; Structural alterations involving BCL2, BCL6, and MYC; Landscape of somatic mutations
• Understand the laboratory tests used to assess the molecular changes seen in DLBCL, including: PCR; FISH; Sanger sequencing; Gene Expression Profiling; Next Generation Sequencing
• Understand how to integrate and apply appropriate molecular testing in routine clinical assessment of DLBCL
Description
This presentation will provide the participants with an understanding of the both the pathological and molecular work-up of B-cell lymphoma and how these results are interpreted and integrated into a pathology report.
