Home Events B-cells Behaving Badly: A Better Basis To Behold Belligerence In (small) B-cell Neoplasms

B-cells Behaving Badly: A Better Basis To Behold Belligerence In (small) B-cell Neoplasms


May 05 2021


11:00 am - 12:30 pm


  • Dr. Adam Bagg
    Dr. Adam Bagg

    Adam Bagg attended Medical School at the Wits University in South Africa, where he also completed training in Laboratory Hematology/Hematopathology. In 1989, he came to the US for a fellowship, but he was impossible to get rid of, and has remained there ever since. He spent a decade at Georgetown University, repeated training (the price foreigners have to pay!) and subsequently joined the faculty. Currently, Dr. Bagg is a Professor of Pathology and Laboratory Medicine at the University of Pennsylvania. He has received a number of teaching awards, including two from Thomas Jefferson University, which is kind of weird since he doesn’t even work there. For the past 10 years, he was voted by his peers as one of Philadelphia’s “Top Doctors” and by US News and World Report to be in the top 1% of doctors in the US. Dr. Bagg has lectured extensively nationally and internationally. He has over 210 full-length publications (peer-reviewed articles, invited reviews and textbook chapters).


Different genetic features underlie different small B-cell neoplasms that include follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, marginal zone lymphomas, lymphoplasmacytic lymphoma and hairy cell leukemia. During this session these different genetic abnormalities with be discussed, with an emphasis on distinguishing which are of diagnostic relevance and which are prognostically pertinent, while others can be used to direct therapy. While these abnormalities help explain the biology of these diverse neoplasms, and although testing for them is quite widely available, it is not necessary to perform genetic tests on all small B-cell neoplasms all the time.


  • Describe the genetic features of small B-cell neoplasms
  • Discuss the role of genetic testing in small B-cell neoplasms
  • Determine which genetic tests are of value in small B-cell neoplasms
  • Distinguish diagnostic from prognostic genetic abnormalities in small B-cell neoplasms