Home Events Case 3 – Aml With Preceding Mpn

Case 3 – Aml With Preceding Mpn


May 06 2021


11:40 am - 12:00 pm


  • Dr Larissa Liontos
    Dr Larissa Liontos

    Dr. Larissa Liontos completed the combined MD/PhD program at the University of Toronto in 2012. Her PhD thesis was focused on negative regulators of cytokine receptors and tyrosine kinases in various hematopoietic cells and, in particular, dendritic cells. She completed residency in the Hematological Pathology program at the University of Toronto in 2018. She is currently a Hematological Pathologist at Sunnybrook Health Sciences Centre in Toronto. Her primary interest is in medical education where she instructs residents in various disciplines including anatomic pathology, hematopathology, pediatric and adult hematology. She also has ongoing projects in quality improvement initiatives and biomarkers in MDS and AML.


This is a case presentation highlighting a case of a myeloproliferative neoplasm that has transformed to AML.  The take home points of the presentation are to understand which genetic testing may be important for diagnosis and prognosis of these cases.


  • List MPN subtypes
  • Describe driver mutations in MPNs
  • List prognostic factors in AML with preceding MPN
  • Understand role of p53 in MPN transformation