Home Events Challenging Hematolymphoid Neoplasms Requiring Correlation Between Bone Marrow And Lymph Node Pathology

Challenging Hematolymphoid Neoplasms Requiring Correlation Between Bone Marrow And Lymph Node Pathology


April 25 2022


1:00 pm - 2:30 pm


  • Dr Larissa Liontos
    Dr Larissa Liontos

    Dr. Larissa Liontos completed the combined MD/PhD program at the University of Toronto in 2012. Her PhD thesis was focused on negative regulators of cytokine receptors and tyrosine kinases in various hematopoietic cells and, in particular, dendritic cells. She completed residency in the Hematological Pathology program at the University of Toronto in 2018. She is currently a Hematological Pathologist at Sunnybrook Health Sciences Centre in Toronto. Her primary interest is in medical education where she instructs residents in various disciplines including anatomic pathology, hematopathology, pediatric and adult hematology. She also has ongoing projects in quality improvement initiatives and biomarkers in MDS and AML.

  • Dr Raheem Peerani
    Dr Raheem Peerani

    Dr. Raheem Peerani MD PhD is a hematopathologist affiliated with Sunnybrook Health Sciences Centre and the University of Toronto. He completed his medical undergraduate and Anatomical Pathology training at the University of Toronto followed by a Hematopathology fellowship at Stanford University. His research interests include the development of digital pathology and machine learning tools for prognostication in chronic lymphocytic leukemia (CLL). Outside work, he enjoys running after his toddler, home improvement projects, and volunteering. He and his wife are expecting their second child in May 2022.


In this interactive microscope session, we will be discussing 5 interesting hematolymphoid disorders that either presented first in the bone marrow or at a peripheral lymph node site which required intergration of the pathology at both sites to determine a final diagnosis. We will present the morphology and ancillary studies including flow cytometry, cytogenetic study, and molecular studies where applicable. The cases will include mixed phenotype acute leukemia T/myeloid with the T lymphoblast component only presenting in the lymph node, a high grade B cell lymphoma whose lineage was difficult to determine upon first presentation, a primary bone marrow diffuse large B cell lymphoma requiring all ancillary studies to be performed on the bone marrow which is technically challenging, classical Hodgkin lymphoma which is rarely presents with primary bone marrow involvement, and difficult to diagnosis T cell lymphomas. The attendees will appreciate the technical difficulties in making diagnoses off bone marrow specimens alone and the importance integrating lymph node pathology, radiology, and clinical context prior to make a final diagnosis.


  • Identify the scope of hematolymphoid disorders that require tissue correlation before providing a definitive classification.
  • Assess for morphological features that can be common to CHL and T cell lymphoma involving the bone marrow.
  • Select bone marrow pathology cases requiring ancillary studies for lymphoma prognostication and treatment.
  • To demonstrate an understanding of immunohistochemical stains in lymphoma diagnosis on bone marrow.

Target Audience

Pathologists, Residents

CanMEDS Roles

Medical Expert (the integrating role), Health Advocate, Collaborator, Scholar, Professional