Objectives
1. Understand the classification of neurodegenerative disease.
2. Understand the role of pathology to support the development of in vivo diagnostic and therapy development.
Description
Neurodegenerative diseases are characterised by selective dysfunction and progressive loss of synapses and neurons associated with pathologically altered proteins that deposit primarily in the human brain and spinal cord. Recent discoveries have identified a spectrum of distinct immunohistochemically and biochemically detectable proteins, which serve as a basis for protein-based disease classification. Diagnostic criteria have been updated and disease staging procedures have been proposed. This presentation summarises recent advances in neuropathological diagnosis and reports novel aspects of relevance for general pathological practice.