Home Events Practical Approach to Mismatch Repair Testing in the Gynecologic and Gastrointestinal Tract – Not just a Hereditary Test Anymore!

Practical Approach to Mismatch Repair Testing in the Gynecologic and Gastrointestinal Tract – Not just a Hereditary Test Anymore!

Date

November 10 2021

Time

1:00 pm - 2:30 pm

Speakers

  • Dr Lien Hoang
  • Dr Mary Kinloch
    Dr Mary Kinloch
  • Dr. David Schaeffer
    Dr. David Schaeffer

    Dr. David Schaeffer – Gastrointestinal Pathology: Snapshot Review of Relevant Topics for an Emerging Pathologist

    Dr. Schaeffer is an assistant professor in the Department of Pathology & Laboratory Medicine at University of British Columbia and the Head of the Department of Pathology and Laboratory Medicine at Vancouver General Hospital (VGH) where he practices as a gastrointestinal pathologist. Dr. Schaeffer obtained his medical degree from the Johannes Gutenberg University of Mainz, Germany. After a residency program in Anatomical Pathology in Vancouver he completed his gastrointestinal pathology fellowship at Mount Sinai Hospital in Toronto. Dr. Schaeffer is a co-director of Pancreas Centre BC and also heads the Gastrointestinal Biobank (GIBB) at VGH. He has an active research program focusing predominately on translational research in colonic and pancreatic cancer.

Objectives

1. Describe the role of mismatch repair (MMR) testing in the setting of hereditary cancers, molecular classification of Gastrointestinal and Gynecologic cancers, a predictive marker for immune checkpoint therapy and diagnostic marker.
2. Breakdown the steps for analysis of MMR interpretation for GI and GYN tumours and examine cases with difficult MMR interpretation.
3. Develop a comprehensive quality assurance program for MMR testing.
4. Formulate interpretative comments for clinicians using clear nomenclature to assist in guiding management and trigger appropriate follow-up measures.

Description

The session will utilize a combination of didactic lecture and case-based examples with incorporation of real-time audience participation by electronic polling. This will be completed by providing attendees case-based staining patterns for MMR IHC and asking in a multiple choice format their interpretation choice.