Glial tumors are one of the most common surgical Neuropathology cases and frequently represent a diagnostic challenge. Similar to many other tumor types, both the diagnostic tests and pathologic classifications are evolving. The current approach to diagnosis of low and high grade gliomas, i.e., H&E morphology, immunohistochemistry, and molecular testing, will be reviewed. Similarities to and differences from diagnostic approaches to non-nervous system tumors will be discussed.
Chart the evolution of glioma diagnosis from a morphologic to a combined morphologic / molecular approach.
Describe the genetic abnormalities of the most common glioma subtypes (astrocytomas, oligodendrogliomas, and glioblastomas).
Discuss the role of genetic tests in the diagnosis of gliomas.
Review the use of molecular tests for prognosis and prediction of response to therapy.