Dr. Downes graduated from the Royal College of Surgeons in Ireland medical school and undertook training in surgery followed by a research fellowship in prostate cancer at University College Dublin. She trained in Anatomic Pathology in Dublin, Ireland and then completed a clinical fellowship in genitourinary pathology at the University Health Network, Toronto. Dr Downes is lead Genitourinary pathologist and Division Head of Anatomic Pathology at Sunnybrook Health Sciences Centre and an Associate Professor in Laboratory Medicine and Pathobiology at the University of Toronto. She is actively engaged in teaching at the undergraduate and postgraduate level. Her research interests are in prognostic and predictive biomarkers of urologic malignancy, particularly in prostate and bladder, with a focus on immune infiltrates and determinants of therapeutic response. She is also engaged in collaborative work examining radiology-pathology correlation and pre-clinical prostate cancer research.